• Lancet neurology · Jul 2012

    Review

    HIV-associated opportunistic infections of the CNS.

    • Ik Lin Tan, Bryan R Smith, Gloria von Geldern, Farrah J Mateen, and Justin C McArthur.
    • HIV Neuroscience Program, Johns Hopkins University, Baltimore, MD 21287, USA.
    • Lancet Neurol. 2012 Jul 1;11(7):605-17.

    AbstractSurvival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.Copyright © 2012 Elsevier Ltd. All rights reserved.

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