• Med Clin Barcelona · Mar 2009

    Multicenter Study

    [Usefulness of the administration of intravenous iron sucrose for the correction of preoperative anemia in major surgery patients].

    • Manuel Muñoz, José A García-Erce, Ana I Díez-Lobo, Arturo Campos, Carmen Sebastianes, Elvira Bisbe, and Anaemia Working Group España (AWGE).
    • Departamento de Medicina Transfusional, Facultad de Medicina, Universidad de Málaga, Málaga, España.
    • Med Clin Barcelona. 2009 Mar 7; 132 (8): 303-6.

    Background And ObjectiveThere is a high incidence of perioperative anemia among surgical patients (20%-70%). Preoperative anemia has been linked to an increased postoperative morbidity and mortality, as well as a decreased quality of life of surgical patients. In addition, a low preoperative hemoglobin constitutes an important predictive factor of allogeneic blood transfusion in major surgery. We evaluated the efficacy of intravenous iron sucrose (IVIS) administration for correction of anemia in these patient populations.Patients And MethodData from 84 patients with anemia who were scheduled for major elective surgery (30 colon cancer resections, 33 abdominal hysterectomies, 21 lower limb arthroplasties) and who received preoperative IVIS during 3-5 weeks were propectively collected.ResultsAdministration of IVIS -mean dose (standard deviation): 1000 (440)mg- caused a significant increase of hemoglobin levels -2.0 (1.6)g/dl (p<0.001)- and anemia was resolved in 58% of patients. No life-threatening adverse effect was witnessed.ConclusionsBecause of the low incidence of side effects and the rapid increase of hemoglobin levels, IVIS emerges as a safe, effective drug for treating preoperative anemia in these patient populations.

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