• Jinglan Wang, Max Harry Weil, Takashi Kamohara, Wanchun Tang, Shijie Sun, Kada Klouche, and Joe Bisera.
• Institute of Critical Care Medicine, Palm Springs, CA, USA.
• Crit. Care Med. 2004 Feb 1; 32 (2): 553-8.

ObjectiveLazaroids, a series of 21-aminosteroids, reduce free radical mediated injury after ischemia and reperfusion. We hypothesized that the lazaroid U-74389G would minimize postresuscitation myocardial dysfunction and thereby improve neurologically meaningful survival in a rodent model after resuscitation from 8 mins of ventricular fibrillation.DesignRandomized, controlled laboratory study.SettingUniversity-affiliated research institute.SubjectsSprague-Dawley rats.InterventionsVentricular fibrillation was electrically induced in ten anesthetized Sprague-Dawley rats. The lazaroid agent U-74389G in a dose of 1 mg.kg-1 or its vehicle serving as a placebo was injected into the right atrium after 7 mins of untreated ventricular fibrillation. One minute after injection of the compound, precordial compression was begun together with mechanical ventilation and continued for 6 mins before attempted electrical defibrillation.Measurements And Main ResultsAll animals were successfully resuscitated. Postresuscitation cardiac index, left ventricular end-diastolic pressure, the rate of left ventricular pressure increase measured at a left ventricular pressure of 40 mm Hg, and the maximum rate of left ventricular pressure decline were significantly less impaired in lazaroid-treated animals. This contrasted with control animals, which had significantly greater myocardial impairment, greater neurologic deficit, and lesser duration of survival.ConclusionsThe lazaroid compound U-74389G, administered during cardiac arrest, mitigated postresuscitation myocardial dysfunction and improved survival.

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