• The Laryngoscope · May 1996

    Brain-derived neurotrophic factor and peripheral nerve regeneration: a functional evaluation.

    • D M Shirley, S A Williams, and P M Santos.
    • Division of Otolaryngology, Southern Illinois University, Springfield, 62794, USA.
    • Laryngoscope. 1996 May 1; 106 (5 Pt 1): 629-32.

    AbstractThe potential benefit of brain-derived neurotrophic factor (BDNF) on motor-nerve regeneration after transection injury in 24 adult rats was evaluated after entubulation repair. Gait analysis for ankle angle and tension transduction device (TTD) strain-gauge measurements yielded functional evaluation of regeneration. The BDNF (15 mg/mL) or phosphate buffered saline (control) was injected into the silicone elastomer (Silastic) channel. Gait analysis performed 0, 2, 4, 6, 10, and 12 weeks after injury demonstrated a significant difference between uninjured and injured legs of 23 and 43 degrees, respectively (P<.001, analysis of variance). The TTD evaluation 13 weeks after injury demonstrated a significant decrease in force development of injured compared to uninjured legs, 148 and 58 g, respectively (P<.001). No functional benefits were demonstrated between BDNF-treated versus control-treated animals in either model for a single exposure to BDNF.

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