• Wissam M Chatila, Walter A Wynkoop, Gwendolyn Vance, and Gerard J Criner.
• Department of Pulmonary and Critical Care, Temple University School of Medicine, Philadelphia, PA 19140, USA. chatilw@tuhs.temple.edu
• Chest. 2004 Jan 1; 125 (1): 152115-21.

BackgroundThe prevalence and mortality associated with COPD increases with age, with higher rates observed in whites than African Americans. Causes and explanations for smoking-related racial differences on the respiratory system have not been determined.ObjectiveTo investigate racial differences in smoking patterns and lung function in patients with advanced COPD.DesignRetrospective record review of patients with advanced COPD.SettingOutpatient pulmonary clinic in a tertiary-care urban hospital.PatientsOne hundred sixty patients with advanced COPD (80 African Americans and 80 whites) referred for either lung volume reduction surgery or transplantation evaluation.Data CollectionDemographics, smoking profile, pulmonary function testing, arterial blood gases, and exercise stress tests were compared between African-American and white patients.ResultsDespite comparable pulmonary function, African Americans were younger at presentation and had lower overall pack-years of smoking than whites (58 +/- 10 years vs 62 +/- 8 years, and 44 +/- 23 pack-years vs 66 +/- 31 pack-years, respectively; p < 0.05 [mean +/- SD]). Additionally, African Americans started smoking later in life than whites (18 +/- 5 years vs 16 +/- 4 years). Similarly, women presented at a younger age and smoked less compared to men (58 +/- 9 years vs 62 +/- 9 years, and 49 +/- 28 pack-years vs 61 +/- 29 pack-years, respectively; p < 0.05), without showing any difference in lung function or exercise performance.ConclusionAmong susceptible patients with advanced COPD, African Americans and women seem more prone to the effects of tobacco smoke than their counterparts.

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