• Valery V Likhvantsev, Giovanni Landoni, Dmitry I Levikov, Oleg A Grebenchikov, Yuri V Skripkin, and Rostislav A Cherpakov.
• Anesthesiology and Intensive Care Department, Moscow Regional Research and Clinical Institute, Moscow, Russia.
• J. Cardiothorac. Vasc. Anesth. 2016 Oct 1; 30 (5): 1221-7.

ObjectiveSeveral studies have suggested that the cardioprotective effects of halogenated anesthetics in cardiac surgery result in reduced cardiac biomarker release compared with total intravenous anesthesia (TIVA). These findings came from relatively small randomized clinical trials and meta-analyses. The authors of this study hypothesized that the beneficial effects of volatile anesthetics translate into a reduced length of hospital stay after coronary artery bypass grafting surgery (CABG) with cardiopulmonary bypass.DesignA randomized controlled trial.SettingTwo university hospitals.ParticipantsAdult patients undergoing elective CABG surgery with cardiopulmonary bypass.InterventionsPatients were assigned randomly to 2 following groups: propofol-based TIVA group (n = 431) and sevoflurane group (n = 437).Measurements And Main ResultsThe primary endpoint was hospital length of stay, and the secondary endpoint included postoperative troponin T and N-terminal pro-brain natriuretic peptide release and mortality. In the sevoflurane group, a reduced length of hospital stay was observed compared with the propofol-based TIVA group (10 [9-11] days v 14 [10-16], p<0.001) as were reductions in cardiac troponin T release (0.18 ng/mL v 0.57 ng/mL at 24 hours, p<0.001), in N-terminal pro-brain natriuretic peptide release (633 pg/mL v 878 pg/mL at 24 hours, p<0.001; 482 pg/mL v 1,036 pg/mL at 48 hours, p<0.001), and in mortality at 1-year follow up (17.8% v 24.8%, p = 0.03).ConclusionsAnesthesia with sevoflurane reduced cardiac biomarker release and length of hospital stay after CABG with cardiopulmonary bypass surgery compared with propofol-based TIVA with a possible reduction in 1-year mortality.Copyright © 2016 Elsevier Inc. All rights reserved.

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