• Gil Wernovsky and Daniel J Licht.
• 1Department of Pediatrics, Section of Cardiology, Florida International University, Wertheim College of Medicine, Nicklaus Children's Hospital, Miami, FL. 2Department of Pediatrics, Section of Cardiology, Perelman School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia Philadelphia, PA.
• Pediatr Crit Care Me. 2016 Aug 1; 17 (8 Suppl 1): S232-42.

ObjectivesThe objectives of this review are to discuss the scope of neurologic injuries in newborns with congenital heart disease, the mechanisms of injury, including prenatal, pre-, intra-, and postoperative factors, neurodevelopmental outcomes, and therapeutic strategies for the timely intervention and prevention of neurologic injury.Data SourceMEDLINE and PubMed.ConclusionAt the current time, important research is underway to 1) better understand the developing brain in the fetus with complex congenital heart disease, 2) to identify modifiable risk factors in the operating room and ICU to maximize long-term neurodevelopmental outcomes, and 3) develop strategies to improve family psychosocial health, childhood development, and health-related quality of life following hospital discharge. Crucial in this effort is the identification of an early postoperative surrogate variable with good predictive validity for long-term outcomes. If an appropriate surrogate variable for long-term outcomes can be identified, and measured relatively early after surgical intervention for complex congenital heart disease, reliable clinical trials can be undertaken to improve upon current outcomes.

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