• Young Hwan Lee, Kui Ja Lee, Yong Hun Min, Hee Cheol Ahn, You Dong Sohn, Won Woong Lee, Young Taeck Oh, Gyu Chong Cho, Jeong Yeol Seo, Dong Hyuk Shin, Sang O Park, and Seung Min Park.
• Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Republic of Korea; Department of emergency medicine, College of Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea. Electronic address: hwaniyo@naver.com.
• Resuscitation. 2016 Oct 1; 107: 150-5.

AimsThis study aimed to evaluate the effects of esmolol treatment for patients with refractory ventricular fibrillation (RVF) in out-of-hospital cardiac arrest (OHCA).MethodsThis single-centre retrospective pre-post study evaluated patients who were treated between January 2012 and December 2015. Some patients had received esmolol (loading dose: 500μg/kg, infusion: 0-100μg/kg/min) for RVF (≥3 defibrillation attempts), after obtaining consent from the patient's guardian.ResultsTwenty-five patients did not receive esmolol (the control group), and 16 patients received esmolol. Sustained return of spontaneous circulation (ROSC) was significantly more common in the esmolol group, compared to the control group (56% vs. 16%, p=0.007). Survival and good neurological outcomes at 30 days, 3 months and at 6 months were >2-fold better in the esmolol group, compared to the control group, although these increases were not statistically significant.ConclusionsThe findings of our study suggest that administration of esmolol may increase the rate of sustained ROSC and ICU survival among patients with RVF in OHCA. Further larger-scale, prospective studies are necessary to determine the effect of esmolol for RVF in OHCA.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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