• J Clin Anesth · Nov 2016

    Randomized Controlled Trial

    Low-dose butorphanol alleviates remifetanil-induced hyperalgesia in patients undergoing laparoscopic cholecystectomy.

    • Mingjian Kong, Li Yang, Jing Li, Zheng Zhong, Yanqiang Cheng, Zhen Wu, and Ran Guo.
    • Department of Anesthesia, The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, People's Republic of China. Electronic address: mjkong@126.com.
    • J Clin Anesth. 2016 Nov 1; 34: 41-5.

    ObjectiveTo evaluate the effects of low-dose butorphanol on hyperalgesia induced by high-dose remifetanil in patients undergoing laparoscopic cholecystectomy.DesignRandomized double-blind clinical trial.SettingIntraoperative.PatientsSeventy-five patients scheduled for laparoscopic cholecystectomy were enrolled.InterventionsRandomly allocated into 3 groups, low dose of remifentanil (LR) group and high dose of remifentanil (HR) group received low (0.1μg kg(-1) min(-1)) or high (0.3μg kg(-1) min(-1)) doses of remifentanil, respectively, and butorphanol combined with remifentanil (BR) group received remifentanil (0.3μg kg(-1) min(-1)) and butorphanol (0.2μg/kg).MeasurementsThe visual analog scale scores and cumulative consumption of fentanyl were recorded.Main ResultsVisual analog scale scores were significantly higher in the HR group than in the LR and BR groups (P<.001). The dose of intravenously given fentanyl was significantly higher in the HR group than in the LR and BR groups (P<.001). In addition, the HR group showed a significantly higher cumulative consumption of fentanyl during 5 to 8 hours after the operation (P<.001).ConclusionsA high dose of remifentanil induces postoperative hyperalgesia, which could be prevented by a continuous intravenous administration of a low dose of butorphanol.Copyright © 2016 Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…