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- Khaled Ezzedine, Maxine Whitton, and Mariona Pinart.
- Department of Dermatology, Henri Mondor Hospital and EpiDermE, Université Paris-Est Créteil Val-de-Marne, Créteil, France.
- JAMA. 2016 Oct 25; 316 (16): 1708-1709.
Clinical QuestionWhich interventions are associated with highest efficacy and fewest adverse events for treating vitiligo?Bottom LineCombination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo. However, combination therapies were associated with more adverse effects.
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