• Ian R Drennan, Erin Case, P Richard Verbeek, Joshua C Reynolds, Zachary D Goldberger, Jamie Jasti, Mark Charleston, Heather Herren, Ahamed H Idris, Paul R Leslie, Michael A Austin, Yan Xiong, Robert H Schmicker, Laurie J Morrison, and Resuscitation Outcomes Consortium Investigators.
• Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, 30 Bond St. Toronto, Ontario M5B 1W8, Canada. Electronic address: DrennanI@smh.ca.
• Resuscitation. 2017 Feb 1; 111: 96-102.

IntroductionThe Universal Termination of Resuscitation (TOR) Guideline accurately identifies potential out-of-hospital cardiac arrest (OHCA) survivors. However, implementation is inconsistent with some Emergency Medical Service (EMS) agencies using absence of return of spontaneous circulation (ROSC) as sole criterion for termination.ObjectiveTo compare the performance of the Universal TOR Guideline with the single criterion of no prehospital ROSC. Second, to determine factors associated with survival for patients transported without a ROSC. Lastly, to compare the impact of time to ROSC as a marker of futility to the Universal TOR Guideline.DesignRetrospective, observational cohort study.ParticipantsNon-traumatic, adult (≥18 years) OHCA patients of presumed cardiac etiology treated by EMS providers.SettingROC-PRIMED and ROC-Epistry post ROC-PRIMED databases between 2007 and 2011.OutcomesPrimary outcome was survival to hospital discharge and the secondary outcome was functional survival. We used multivariable regression to evaluate factors associated with survival in patients transported without a ROSC.Results36,543 treated OHCAs occurred of which 9467 (26%) were transported to hospital without a ROSC. Patients transported without a ROSC who met the Universal TOR Guideline for transport had a survival of 3.0% (95% CI 2.5-3.4%) compared to 0.7% (95% CI 0.4-0.9%) in patients who met the Universal TOR Guideline for termination. The Universal TOR Guideline identified 99% of survivors requiring continued resuscitation and transportation to hospital including early identification of survivors who sustained a ROSC after extended durations of CPR.ConclusionUsing absence of ROSC as a sole predictor of futility misses potential survivors. The Universal TOR Guideline remains a strong predictor of survival.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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