• JAMA · Jul 2015

    Comment

    Long-term vs Short-term Therapy With Vitamin K Antagonists for Symptomatic Venous Thromboembolism.

    • Saskia Middeldorp and Barbara A Hutten.
    • Department of Vascular Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.
    • JAMA. 2015 Jul 7;314(1):72-3.

    Clinical QuestionIs long-term (≥3 months) vs short-term therapy with vitamin K antagonists (VKAs) associated with differences in the incidence of recurrent venous thromboembolism (VTE), major bleeding, and mortality in patients with symptomatic VTE?Bottom LineLong-term treatment with VKAs is associated with a reduced risk for recurrent VTE and an increased risk for major bleeding compared with short-term treatment in patients with VTE, but is not associated with differences in mortality.

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