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- Tomoyuki Fukuda, Nanaho Fukuda, Ana Agostinho, Abrahan Hernández-Hernández, Anna Kouznetsova, and Christer Höög.
- Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden tfukuda@bs.naist.jp christer.hoog@ki.se.
- EMBO J. 2014 Jun 2; 33 (11): 1243-55.
AbstractCohesion between sister chromatids in mitotic and meiotic cells is promoted by a ring-shaped protein structure, the cohesin complex. The cohesin core complex is composed of four subunits, including two structural maintenance of chromosome (SMC) proteins, one α-kleisin protein, and one SA protein. Meiotic cells express both mitotic and meiosis-specific cohesin core subunits, generating cohesin complexes with different subunit composition and possibly separate meiotic functions. Here, we have analyzed the in vivo function of STAG3, a vertebrate meiosis-specific SA protein. Mice with a hypomorphic allele of Stag3, which display a severely reduced level of STAG3, are viable but infertile. We show that meiocytes in homozygous mutant Stag3 mice display chromosome axis compaction, aberrant synapsis, impaired recombination and developmental arrest. We find that the three different α-kleisins present in meiotic cells show different dosage-dependent requirements for STAG3 and that STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.© 2014 The Authors.
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