• J. Neurosci. · Jun 2010

    The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.

    • Esther Breunig, Ivan Manzini, Fabiana Piscitelli, Benjamin Gutermann, Vincenzo Di Marzo, Detlev Schild, and Dirk Czesnik.
    • Department of Neurophysiology and Cellular Biophysics, University of Göttingen, 37073 Göttingen, Germany.
    • J. Neurosci. 2010 Jun 30; 30 (26): 8965-73.

    AbstractCannabinoids modulate the activity of many neuronal cells, among them sensory neurons in the olfactory epithelium. Here we show that the endocannabinoid 2-arachidonoyl-glycerol (2-AG) is synthesized in both olfactory receptor neurons and glia-like sustentacular cells in larval Xenopus laevis. Its production in the latter depends on the hunger state of the animal. The essential effect of 2-AG in olfactory receptor neurons is the control of odorant detection thresholds via cannabinoid CB(1) receptor activation. Hunger renders olfactory neurons more sensitive. Endocannabinoid modulation in the nose may therefore substantially influence food-seeking behavior.

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