• The lancet oncology · Apr 2014

    Review

    Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review.

    • Aimilios Lallas, Athanassios Kyrgidis, Gerardo Ferrara, Harald Kittler, Zoe Apalla, Fabio Castagnetti, Caterina Longo, Elvira Moscarella, Simonetta Piana, Iris Zalaudek, and Giuseppe Argenziano.
    • Skin Cancer Unit, Arcispedale Santa Maria Nuova Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy.
    • Lancet Oncol. 2014 Apr 1; 15 (4): e178-83.

    AbstractSentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours.Copyright © 2014 Elsevier Ltd. All rights reserved.

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