• JAMA · Jun 2014

    Comment

    Topical and systemic antimicrobial therapy for venous leg ulcers.

    • Susan O'Meara, Rachel Richardson, and Benjamin A Lipsky.
    • School of Healthcare, Baines Wing, University of Leeds, England.
    • JAMA. 2014 Jun 25;311(24):2534-5.

    Clinical QuestionIs treatment with topical or systemic antimicrobial agents associated with better venous leg ulcer healing compared with usual care (dressings and bandages without antimicrobials) or an alternative topical or systemic antimicrobial agent?Bottom LineAvailable evidence, from underpowered pooled data, neither supports nor refutes an association of systemic antibiotic therapy with improved venous leg ulcer healing. Among topical antimicrobials, cadexomer iodine may be associated with better healing compared with usual care.

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