• Jianfang Zhou, Hongcheng Tian, Xueping Du, Xiuming Xi, Youzhong An, Meili Duan, Li Weng, Bin Du, and for China Critical Care Clinical Trials Group (CCCCTG).
• 1Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.2Department of Critical Care Medicine, China Rehabilitation Research Center, Beijing, China.3Department of General Internal Medicine, Fuxing Hospital, Capital Medical University, Beijing, China.4Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China.5Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China.6Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
• Crit. Care Med. 2017 Jul 1; 45 (7): 1168-1176.

ObjectiveInformation about the epidemiology of sepsis in community residents in China remains scarce and incomplete. The purpose of this study was to describe the occurrence rate and outcome of sepsis in Yuetan Subdistrict of Beijing and to estimate the occurrence rate of sepsis in China.DesignRetrospective cohort study.SettingAll public hospitals serving residents in Yuetan Subdistrict, Beijing.PatientsAll patients (n = 1,716) meeting criteria for sepsis based on American College of Chest Physicians/Society of Critical Care Medicine consensus definition.InterventionsNone.Measurement And Main ResultsWe screened all adult residents in Yuetan Subdistrict who were hospitalized from July 1, 2012, to June 30, 2014, and reviewed medical records. Patients with sepsis were included in the analysis. We enrolled 1,716 patients with sepsis out of 21,191 hospitalized adults screened, among whom severe sepsis developed in 256 patients, and septic shock developed in 233 patients. The crude annual occurrence rates of sepsis, severe sepsis, and septic shock in Yuetan Subdistrict were 667, 103, and 91 cases per 100,000 population, corresponding to standardized occurrence rates of 461, 68, and 52 cases per 100,000 population per year, respectively. Both occurrence rate and mortality increased significantly with age, although males had higher age-adjusted occurrence rate and mortality. The occurrence rate of sepsis also exhibited seasonal variation, peaking in winter season. The overall hospital mortality rate of sepsis was 20.6%, yielding a standardized mortality rate of 79 cases per 100,000 population per year.ConclusionsSepsis is a common and frequently fatal syndrome in Yuetan Subdistrict, Beijing. The occurrence rate and mortality of sepsis are significantly higher in males and elderly people.

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