• Niema M Pahlevan, Derek G Rinderknecht, Peyman Tavallali, Marianne Razavi, Thao T Tran, Michael W Fong, Robert A Kloner, Marie Csete, and Morteza Gharib.
• 1Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA.2Advanced Imaging and Spectroscopy Center, Huntington Medical Research Institutes, Pasadena, CA.3Avicena LLC, Los Angeles, CA.4Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA.5Medical Engineering Department, California Institute of Technology, Pasadena, CA.6Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.7Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, CA.8Department of Anesthesiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.9Graduate Aerospace Laboratory, California Institute of Technology, Pasadena, CA.
• Crit. Care Med. 2017 Jul 1; 45 (7): 1115-1120.

ObjectiveThe study is based on previously reported mathematical analysis of arterial waveform that extracts hidden oscillations in the waveform that we called intrinsic frequencies. The goal of this clinical study was to compare the accuracy of left ventricular ejection fraction derived from intrinsic frequencies noninvasively versus left ventricular ejection fraction obtained with cardiac MRI, the most accurate method for left ventricular ejection fraction measurement.DesignAfter informed consent, in one visit, subjects underwent cardiac MRI examination and noninvasive capture of a carotid waveform using an iPhone camera (The waveform is captured using a custom app that constructs the waveform from skin displacement images during the cardiac cycle.). The waveform was analyzed using intrinsic frequency algorithm.SettingOutpatient MRI facility.SubjectsAdults able to undergo MRI were referred by local physicians or self-referred in response to local advertisement and included patients with heart failure with reduced ejection fraction diagnosed by a cardiologist.InterventionsStandard cardiac MRI sequences were used, with periodic breath holding for image stabilization. To minimize motion artifact, the iPhone camera was held in a cradle over the carotid artery during iPhone measurements.Measurements And Main ResultsRegardless of neck morphology, carotid waveforms were captured in all subjects, within seconds to minutes. Seventy-two patients were studied, ranging in age from 20 to 92 years old. The main endpoint of analysis was left ventricular ejection fraction; overall, the correlation between ejection fraction-iPhone and ejection fraction-MRI was 0.74 (r = 0.74; p < 0.0001; ejection fraction-MRI = 0.93 × [ejection fraction-iPhone] + 1.9).ConclusionsAnalysis of carotid waveforms using intrinsic frequency methods can be used to document left ventricular ejection fraction with accuracy comparable with that of MRI. The measurements require no training to perform or interpret, no calibration, and can be repeated at the bedside to generate almost continuous analysis of left ventricular ejection fraction without arterial cannulation.

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