• Mine Altınkaya Chavush, Seyhan Yağar, Ayşim Ertürk, and Ayşegül Özgök.
• Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
• J Clin Anesth. 2017 Sep 1; 41: 137-140.

Study ObjectiveTo determine the efficacy of 2 different doses (150-300mg) of preoperative pregabalin on propofol and remifentanil doses for total intravenous anesthesia in laparoscopic cholecystectomy.DesignProspective, randomized, placebo-controlled, double-blinded study.SettingTraining and research hospital.PatientsForty-eight adult, American Society of Anesthesiologists physical status 1 and 2 patients.InterventionsPatients were randomly assigned to 3 groups to receive orally 1hour before surgery, a placebo group (group 1), pregabalin 150mg (group 2), or pregabalin 300mg (group 3).MeasurementsIn the operating room, heart rate, systolic and diastolic blood pressures, SpO2, bispectral index, and body temperature were recorded just before anesthesia induction; 1 and 5minutes after induction; and at minutes 10, 15, 20, 25, 30, 35, and 40 of the surgery. Required propofol and remifentanil doses to obtain bispectral index value less than 60 were also recorded.Main ResultsThe remifentanil doses used in the pregabalin groups at minutes 10, 15, 20, 25, and 30 and propofol doses at minutes 15, 20, 25, and 30 were statistically significantly lower in comparison to the placebo group.ConclusionThe observations provide preliminary evidence that preoperative pregabalin may decrease anesthetic agent requirement in total intravenous anesthesia patients.Copyright © 2016 Elsevier Inc. All rights reserved.

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