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  • J Headache Pain · Sep 2017

    Brain networking analysis in migraine with and without aura.

    • Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R Siugzdaite, and Sebastiano Stramaglia.
    • Applied Neurophysiology and Pain Unit, Basic Medical, Neuroscience and Sensory System -SMBNOS- Department, Bari Aldo Moro University, Giovanni XXIII Building, Policlinico General Hospital, Via Amendola 207 A, 70124, Bari, Italy. marina.detommaso@uniba.it.
    • J Headache Pain. 2017 Sep 29; 18 (1): 98.

    BackgroundTo apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial frequency in migraine with aura (MA) and without aura (MO), and to compare these findings with Blood Oxygen Level Dependent (BOLD) signal changes.MethodsNineteen asymptomatic MA and MO patients and 11 age and sex matched controls (C) were recorded by 65 EEG channels. The same visual stimulation was employed to evaluate BOLD signal changes in a subgroup of MA and MO. The GC and brain networking were applied to EEG signals.ResultsA different pattern of reduced vs increased GC respectively in MO and MA patients, emerged in resting state. During visual stimulation, both MA and MO showed increased information transfer toward the fronto-central regions, while MA patients showed a segregated cluster of connections in the posterior regions, and an increased bold signal in the visual cortex, more evident at 2 cpd spatial frequency.ConclusionsThe wealth of information exchange in the parietal-occipital regions indicates a peculiar excitability of the visual cortex, a pivotal condition for the manifestation of typical aura symptoms.

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