• J Clin Anesth · Dec 2017

    Meta Analysis

    Nonsteroidal anti-inflammatory drugs for postoperative pain control after lumbar spine surgery: A meta-analysis of randomized controlled trials.

    • Zhifeng Zhang, Haihua Xu, Yunhui Zhang, Wei Li, Yanjie Yang, Tian Han, Zhihui Wei, Xue Xu, and Jingui Gao.
    • Department of Pain Treatment, the Second Hospital of Tianjin Medical University, Tianjin 300211, China.
    • J Clin Anesth. 2017 Dec 1; 43: 84-89.

    Study ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) play a role in pain relief, especially in postoperative pain caused by inflammation. They have demonstrated significant opioid dose-sparing effects, which help in reducing postoperative effects and opioid side effects. The objective of this meta-analysis was to explore the role of NSAIDs in reducing postoperative pain at different time intervals and provide reference for medication after lumbar spine surgery by a meta-analysis of randomized controlled trials (RCT).DesignA meta-analysis study of randomized controlled trials.SettingPostoperative recovery area.PatientsAdult patients who have undergone lumbar spine surgery.InterventionPatients received NSAIDs for pain control after lumbar spine surgery.MeasurementsStandardized mean difference (SMD) and 95%CI were used to evaluate the visual analog scale of postoperative pain.Main ResultsFour hundred and eight participants from eight studies were included in this study. The difference between the NSAIDs group and placebo is significant in 0-6, 12, and 24h groups (overall: SMD=-0.72, 95%CI -0.98 to -0.45; 0-6h: SMD=0.50, 95%CI -0.81 to -0.19; 12h: SMD=-1.07, 95%CI -1.45 to -0.70; 24h: SMD=-1.16, 95%CI -1.87 to -0.45). Heterogeneity and publication bias were observed in the 0-6 and 24h groups.ConclusionNSAIDs are effective in postoperative analgesia after lumbar spine surgery. The study type, NSAID dose, different surgery types, and analgesic type might influence the efficacy of NSAIDs.Copyright © 2017 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation  

      Add institutional full text...


    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..


Want more great medical articles?

Keep up to date with a free trial of metajournal, personalized for your practice.
988,657 articles already indexed!

We guarantee your privacy. Your email address will not be shared.