• Takeshi Takahara, Go Wakabayashi, Toru Beppu, Arihiro Aihara, Kiyoshi Hasegawa, Naoto Gotohda, Etsuro Hatano, Yoshinao Tanahashi, Toru Mizuguchi, Toshiya Kamiyama, Tetsuo Ikeda, Shogo Tanaka, Nobuhiko Taniai, Hideo Baba, Minoru Tanabe, Norihiro Kokudo, Masaru Konishi, Shinji Uemoto, Atsushi Sugioka, Koichi Hirata, Akinobu Taketomi, Yoshihiko Maehara, Shoji Kubo, Eiji Uchida, Hiroaki Miyata, Masafumi Nakamura, Hironori Kaneko, Hiroki Yamaue, Masaru Miyazaki, and Tadahiro Takada.
• Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.
• J Hepatobiliary Pancreat Sci. 2015 Oct 1; 22 (10): 721-7.

BackgroundThe aim of this study was to compare the long-term outcomes and perioperative outcomes of laparoscopic liver resection (LLR) with those of open liver resection (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups.MethodsHepatocellular carcinoma patients underwent primary liver resection between 2000 and 2010, were collected from 31 participating institutions in Japan and were divided into LLR (n = 436) and OLR (n = 2969) groups. A one-to-one propensity case-matched analysis was used with covariates of baseline characteristics, including tumor characteristics and surgical procedures of hepatic resections. Long-term and short-term outcomes were compared between the matched two groups.ResultsThe two groups were well balanced by propensity score matching and 387 patients were matched. There were no significant differences in overall survival and disease-free survival between LLR and OLR. The median blood loss (158 g vs. 400 g, P < 0.001) was significantly less with LLR, and the median postoperative hospital stay (13 days vs. 16 days, P < 0.001) was significantly shorter for LLR. Complication rate (6.7% vs. 13.0%, P = 0.003) was significantly less in LLR.ConclusionCompared with OLR, LLR in selected patients with HCC showed similar long-term outcomes, associated with less blood loss, shorter hospital stay, and fewer postoperative complications.© 2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

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