• Curr Opin Pulm Med · Jan 2014

    Review

    Childhood asthma: recent developments and update.

    • Eva Mantzouranis, Eva Papadopouli, and Eleni Michailidi.
    • Department of Pediatrics, University Hospital, Heraklion, Crete, Greece.
    • Curr Opin Pulm Med. 2014 Jan 1; 20 (1): 8-16.

    Purpose Of ReviewThe purpose of this review is to provide an update on childhood asthma specifically related to the underlying genetic background and pathophysiology of asthma and their interaction with environmental stimuli. We will also discuss emerging data in the field of disease phenotyping.Recent FindingsThe field of genetics is continuously evolving to expand our knowledge on the cause of disease. Childhood onset asthma has been related to atopy and exposure to early-life infections. More recently, phenotypes have been used to classify asthma as transient and persistent, but the association of each phenotype with the genetic origin of asthma is not clearly understood.SummaryThis review covers the topics of genetics, epigenetics, pathophysiology, phenotypes and treatment as they relate to childhood asthma. Overall, it provides a basis for the future of asthma treatment through description of the current research.

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