• Surg J R Coll Surg E · Aug 2016

    Review

    Is treatment de-escalation a reality in HPV related oropharyngeal cancer?

    • J C Oosthuizen and J B Kinsella.
    • St. James's Hospital, Dublin, Ireland. Electronic address: C.Oosth@gmail.com.
    • Surg J R Coll Surg E. 2016 Aug 1; 14 (4): 180-3.

    AbstractThe incidence of HPV related oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing. It is now well recognised as a distinct clinical and biologic entity, compared to traditional OPSCC. The majority of these patients have an excellent prognosis due to the chemo-radiosensitive nature of these tumours. The de-escalation of current treatment regimens have therefore been proposed in an attempt to reduce the long term treatment related morbidity of this much younger patient cohort. Several of the more pertinent points regarding safe de-escalation strategies are considered within this manuscript.Copyright © 2016. Published by Elsevier Ltd.

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