• Brian Chambers, Jayne Chambers, Leonid Churilov, Heather Cameron, and Richard Macdonell.
• Department of Neurology, Austin Health, Melbourne, Australia The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia Department of Medicine, University of Melbourne, Victoria, Australia brc@bigpond.net.au.
• Phlebology. 2014 Sep 1; 29 (8): 528-35.

Objectives & MethodsWe evaluated internal jugular vein and vertebral vein volume flow using ultrasound, in patients with clinically isolated syndrome or mild multiple sclerosis and controls, to determine whether volume flow was different between the two groups.ResultsIn patients and controls, internal jugular vein volume flow increased from superior to inferior segments, consistent with recruitment from collateral veins. Internal jugular vein and vertebral vein volume flow were greater on the right in supine and sitting positions. Internal jugular vein volume flow was higher in the supine posture. Vertebral vein volume flow was higher in the sitting posture. Regression analyses of cube root transformed volume flow data, adjusted for supine/sitting, right/left and internal jugular vein/vertebral vein, revealed no significant difference in volume flow in patients compared to controls.ConclusionsOur findings further refute the concept of venous obstruction as a causal factor in the pathogenesis of multiple sclerosis. Control volume flow data may provide useful normative reference values.© The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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