• BMC anesthesiology · Dec 2017

    Effects of sevoflurane and propofol on the development of pneumonia after esophagectomy: a retrospective cohort study.

    • Guo-Hua Zhang and Wen Wang.
    • Department of Anesthesiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuannanli Road, Chaoyang District, Beijing, 100021, China. d1974@163.com.
    • BMC Anesthesiol. 2017 Dec 4; 17 (1): 164.

    BackgroundPostoperative pneumonia (PP) is one of the common complications following esophagectomy and associated with poor short- and long-term outcomes. Sevoflurane and propofol, which have inflammatory-modulating effects, are common used general anesthetics. This study aimed to compare the effects of anesthesia with sevoflurane and propofol on the development of PP after esophageal surgery for cancer.MethodsThe electronic medical records of patients who underwent elective esophagectomy between July 2013 and July 2016 were reviewed. We conducted univariate and multivariate logistics analysis and propensity score matching analysis to compare the effect of sevoflurane and propofol on the incidence of PP and to identify the risk factors for PP after esophagectomy.ResultsOverall, the incidence of postoperative pneumonia was 9.5%. There was no significant difference in the rates of PP between sevoflurane group and propofol group either before or after propensity score matching (9.6% vs 8.0%, P = 0.606; 7.7% vs 6.4%, P = 0.754, respectively). Univariate and multivariate analysis revealed that alcohol use (OR 1.513; 95% CI 1.062-2.156), surgical procedure (Sweet: referent; Ivor-Lewis: OR 1.993; 95% CI 1.190-3.337; Three-incision: OR 1.878; 95% CI 1.296-2.722) and surgeon experience (high-volume: referent; low-volume: OR 1.525; 95% CI 1.090-2.135) were significant risk factors of postoperative pneumonia.ConclusionsSevoflurane did not differ from propofol in terms of affecting the risk of PP development after esophagectomy.

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