• Chron Respir Dis · Feb 2015

    Review

    Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

    • Binita Kane, Stephen J Fowler, and Rob Niven.
    • Manchester Academic Health Science Centre, University Hospital of South Manchester, University of Manchester, Southmoor Road, Manchester, UK binita.kane@doctors.org.uk.
    • Chron Respir Dis. 2015 Feb 1; 12 (1): 69-77.

    AbstractA small percentage of asthmatics have 'severe refractory asthma', where there is suboptimal response to currently available therapies. A number of novel therapies targeting key biological targets are becoming available. Asthma is a heterogeneous disease, and systematic evaluation of patients is important to target therapies to the underlying inflammatory subtype and clinical features. This review article outlines new and emerging treatments for severe asthma, including monoclonal antibodies targeting eosinophilic disease, anti-neutrophil strategies, novel bronchodilators and bronchial thermoplasty. We highlight the importance of individualized investigation, treatment and management of severe asthmatics. © The Author(s) 2014.

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