• Claudia A Angeli, Maxwell Boakye, Rebekah A Morton, Justin Vogt, Kristin Benton, Yangshen Chen, Christie K Ferreira, and Susan J Harkema.
• From the Frazier Rehabilitation Institute (C.A.A., R.A.M., J.V., K.B., S.J.H.), and the Kentucky Spinal Cord Injury Research Center (C.A.A., M.B., Y.C., C.K.F., S.J.H.) and the Department of Neurosurgery, School of Medicine (M.B., R.A.M., J.V., K.B., Y.C., C.K.F., S.J.H.), University of Louisville - all in Louisville, KY.
• N. Engl. J. Med. 2018 Sep 27; 379 (13): 1244-1250.

AbstractPersons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention of some sensation, do not recover independent walking. We tested intense locomotor treadmill training with weight support and simultaneous spinal cord epidural stimulation in four patients 2.5 to 3.3 years after traumatic spinal injury and after failure to improve with locomotor training alone. Two patients, one with damage to the mid-cervical region and one with damage to the high-thoracic region, achieved over-ground walking (not on a treadmill) after 278 sessions of epidural stimulation and gait training over a period of 85 weeks and 81 sessions over a period of 15 weeks, respectively, and all four achieved independent standing and trunk stability. One patient had a hip fracture during training. (Funded by the Leona M. and Harry B. Helmsley Charitable Trust and others; ClinicalTrials.gov number, NCT02339233 .).

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