• Mayur B Patel, Josef Bednarik, Patricia Lee, Yahya Shehabi, Jorge I Salluh, Arjen J Slooter, Kate E Klein, Yoanna Skrobik, Alessandro Morandi, Peter E Spronk, Andrew M Naidech, Brenda T Pun, Fernando A Bozza, Annachiara Marra, Sayona John, Pratik P Pandharipande, and E Wesley Ely.
• Critical Illness, Brain dysfunction, and ICU Survivorship (CIBS) Center, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN.
• Crit. Care Med. 2018 Nov 1; 46 (11): 183218411832-1841.

ObjectivesThe Society of Critical Care Medicine recommends routine delirium monitoring, based on data in critically ill patients without primary neurologic injury. We sought to answer whether there are valid and reliable tools to monitor delirium in neurocritically ill patients and whether delirium is associated with relevant clinical outcomes (e.g., survival, length of stay, functional independence, cognition) in this population.Data SourcesWe systematically reviewed Cumulative Index to Nursing and Allied Health Literature, Web of Science, and PubMed.Study Selection And Data ExtractionInclusion criteria allowed any study design investigating delirium monitoring in neurocritically ill patients (e.g., neurotrauma, ischemic, and/or hemorrhagic stroke) of any age. We extracted data relevant to delirium tool sensitivity, specificity, negative predictive value, positive predictive value, interrater reliability, and associated clinical outcomes.Data SynthesisAmong seven prospective cohort studies and a total of 1,173 patients, delirium was assessed in neurocritically patients using validated delirium tools after considering primary neurologic diagnoses and associated complications, finding a pooled prevalence rate of 12-43%. When able to compare against a common reference standard, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, the test characteristics showed a sensitivity of 62-76%, specificity of 74-98%, positive predictive value of 63-91%, negative predictive value of 70-94%, and reliability kappa of 0.64-0.94. Among four studies reporting multivariable analyses, delirium in neurocritically patients was associated with increased hospital length of stay (n = 3) and ICU length of stay (n = 1), as well as worse functional independence (n = 1) and cognition (n = 2), but not survival.ConclusionsThese data from studies of neurocritically ill patients demonstrate that patients with primary neurologic diagnoses can meet diagnostic criteria for delirium and that delirious features may predict relevant untoward clinical outcomes. There is a need for ongoing investigations regarding delirium in these complicated neurocritically ill patients.

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