• Mark A Atkinson, George S Eisenbarth, and Aaron W Michels.
• Department of Pathology and Department of Pediatrics, University of Florida, Gainesville, FL, USA. Electronic address: atkinson@ufl.edu.
• Lancet. 2014 Jan 4;383(9911):69-82.

AbstractOver the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease.Copyright © 2014 Elsevier Ltd. All rights reserved.

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