• Yılmaz Ünal, Berkay Küçük, Salih Tuncal, Koray Koşmaz, Nadir Turgut Çavuşoğlu, Kemal Kısmet, Mehmet Şeneş, Pınar Celepli, Murat Durak, and Sema Hücümenoğlu.
• Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkey. yilmazunal66@mynet.com.
• Ulus Travma Acil Cer. 2018 Sep 1; 24 (5): 391-397.

BackgroundThis study investigates the protective effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on experimental liver ischemia-reperfusion injury (IRI).MethodsForty rats were divided into four groups. In Group 1, (sham), only hepatic pedicle was induced. In Group 2 (control), hepatic pedicle was reperfused for 90 min after being clamped for 60 min. No treatment was given in Group 1 and 2. In Group 3 (perioperative CaDob), 100 mg/kg CaDob was given 2 hours prior to the operation in which hepatic pedicle was reperfused for 90 min following a 60-min clamp. In Group 4 (preoperative CaDob), after 100 mg/kg/day CaDob was given for 10 days before the operation, hepatic pedicle was clamped for 60 min and reperfused for 90 minutes. At the end of these procedures, blood and liver tissue samples were collected for biochemical and histopathological assessment.ResultsLiver function tests and tissue oxidative stress parameters were significantly lower in the preoperative and perioperative treatment groups than the control group. Furthermore, it was observed that histopathological injury in the control group significantly decreased in both perioperative and preoperative treatment groups.ConclusionCalcium dobesilate demonstrated a significant hepatoprotective effect in terms of its antioxidant and anti-inflammatory effects.

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