• Zhu Zhang, Jieping Lei, Xiang Shao, Fen Dong, Jing Wang, Dingyi Wang, Sinan Wu, Wanmu Xie, Jun Wan, Hong Chen, Yingqun Ji, Qun Yi, Xiaomao Xu, Yuanhua Yang, Zhenguo Zhai, Chen Wang, and China Venous Thromboembolism Study Group.
• Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
• Chest. 2019 Feb 1; 155 (2): 342-353.

BackgroundVTE has emerged as a major public health problem. However, data on VTE burden in China are seldom reported.MethodsThis study collected data on patients with a principal diagnosis of VTE, pulmonary embolism (PE), or DVT by using the International Classification of Diseases, 10th Revision, from 90 hospitals across China. The trends in hospitalization rates, mortality, length of stay (LOS), and comorbidities from 2007 to 2016 were analyzed.ResultsIn total, 105,723 patients with VTE were identified. For patients with VTE, the age- and sex-adjusted hospitalization rate increased from 3.2 to 17.5 per 100,000 population, and in-hospital mortality decreased from 4.7% to 2.1% (P < .001). The mean LOS declined from 14 to 11 days (P < .001). In addition, the data in 2016 showed that the hospitalization rate of VTE was higher in elderly male patients (male patients vs female patients, 155.3 vs 125.4 per 100,000 population in patients aged ≥ 85 years; P < .001) and in northern China (north vs south, 18.4 vs 13.4 per 100,000 population; P < .001). Higher mortality rates were found in patients with cancer and Charlson Comorbidity Index scores > 2. Similar trends were also observed in patients with PE and those with DVT. The hospitalization rate in China was much lower than that of the United States or selected sites in Canada and Europe, the LOS was much longer, and the in-hospital mortality rates were similar.ConclusionsThe hospitalization rates of VTE increased steadily, and the mortality declined. This study provides important information on the disease burden of VTE in China.Copyright © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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