• J Natl Compr Canc Netw · Nov 2017

    Review

    Emerging Role of CAR T Cells in Non-Hodgkin's Lymphoma.

    • Mauro P Avanzi and Renier J Brentjens.
    • From Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, New York, New York.
    • J Natl Compr Canc Netw. 2017 Nov 1; 15 (11): 1429-1437.

    AbstractAdoptive T-cell therapy with chimeric antigen receptor T cells (CAR-Ts) has produced impressive clinical responses among patients with B-cell malignancies, and several groups have published positive results using anti-CD19 CAR-Ts for the treatment of B-cell acute lymphoblastic leukemia. Recently, new data from clinical trials have demonstrated the benefits of CAR-T therapy in the non-Hodgkin's lymphoma (NHL) setting. This review describes some of the most recent and promising advances in engineered T-cell therapy, with particular emphasis on the clinical benefits of NHL treatment.Copyright © 2017 by the National Comprehensive Cancer Network.

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