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- H K R Thanacoody.
- Scottish Poisons Information Bureau, Royal Infirmary Edinburgh, 51 Little France Crescent, Edinburgh, UK. ruben.thanacoody@luht.scot.nhs.uk
- Emerg Med J. 2007 Sep 1; 24 (9): 677-8.
AbstractA 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4 day history of acute confusion and tremulousness. She had apnoeic episodes, reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 micromol/l (normal 300-600 micromol/l). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.
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