• Jean-Louis Pépin, Ingrid Jullian-Desayes, Marc Sapène, Erika Treptow, Marie Joyeux-Faure, Meriem Benmerad, Sébastien Bailly, Yves Grillet, Bruno Stach, Philippe Richard, Patrick Lévy, Jean-François Muir, and Renaud Tamisier.
• HP2 Laboratory, INSERM U1042, Grenoble Alpes University, Grenoble, France; EFCR Laboratory, Pole Thorax and Vessels, Grenoble Alps University Hospital, Grenoble, France. Electronic address: JPepin@chu-grenoble.fr.
• Chest. 2019 Apr 1; 155 (4): 730-739.

BackgroundThe management of patients with high cardiovascular risk and OSA must target not only improving adherence to CPAP, but should also include strategies aimed at reducing BP and increasing physical activity. The study aims to evaluate the effectiveness of an integrated intervention using remote patient telemonitoring in reducing BP in high cardiovascular risk patients with OSA.MethodsIn a multicenter, open, randomized trial, patients with OSA were randomly assigned at CPAP initiation to usual care or multimodal telemonitoring for 6 months. Telemonitoring used electronic equipment collecting information about BP, symptoms, CPAP side effects, and physical activity with home care providers prespecified protocoled actions. The primary effectiveness outcome was assessed using home self-measured BP on 3 consecutive days. Secondary outcomes included CPAP compliance, symptoms, and physical activity.ResultsOf 306 patients with a median age of 61.3 years [interquartile range, 54.1; 66.1], who were predominantly men, 226 (74%) with a BMI of 32.0 [28.7; 35.6] kg/m2 and an apnea-hypopnea index of 46 [35; 61] events/h, 149 received usual care and 157 received telemonitoring. After 6 months of CPAP, home self-measured BP did not differ significantly between groups. In secondary analyses, there was no significant difference in steps per day, but a significant increase in CPAP adherence and an improvement in daytime sleepiness and quality of life in favor of the multimodal telemonitoring.ConclusionsIn OSA patients with high cardiovascular risk, multimodal telemonitoring was not superior to usual CPAP care for improving home BP; however, telemonitoring improved adherence and patient-centered outcomes.Copyright © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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