• John W Bennett and Paul P Glasziou.
• University Health Service, University of Queensland, Gordon Greenwood Building, Brisbane, Queensland 4072, Australia. j.bennett@sph.uq.edu.au
• Med. J. Aust. 2003 Mar 3; 178 (5): 217-22.

ObjectiveTo systematically review randomised controlled trials (RCTs) of computer-generated medication reminders or feedback directed to healthcare providers or patients.Data SourcesExtensive computerised and manual literature searches identified 76 English-language reports of RCTs reported before 1 January 2002. Searches were conducted between June 1998 and April 2002.Study Selection26 papers making 29 comparisons (two papers reported on multiple interventions) of computer-supported medication management to a control group.Data ExtractionThe quality of the RCTs was systematically assessed and scored independently by two reviewers. Rates of compliance with (potential) reminders for the control and intervention groups were extracted.Data SynthesisHeterogeneity of studies prevented a meta-analysis. Where possible, rates were calculated using the intention-to-treat principle. The comparisons were grouped into five areas. Reminders to providers in outpatient settings: six of 12 comparisons demonstrated positive effects (relative rates [RRs: intervention rates/control rates], 1.0 to 42.0). Provider feedback in outpatient settings: five of seven comparisons showed improved clinician behaviour (RRs, 1.0 to 2.5). Combined reminders and feedback in outpatient settings: the single comparison found no improvement. Reminders to providers in inpatient settings: three of five comparisons showed improvements (RRs, 1.0 to 2.1). Patient-directed reminders: two of four comparisons showed improvements in patient compliance.ConclusionReminders are more effective than feedback in modifying physician behaviour related to medication management. Patient-directed reminders can improve medication adherence.

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