• Sarah Ziegler, Margareta Schmid, Matthias Bopp, Georg Bosshard, and Milo Alan Puhan.
• Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. sarah.ziegler@uzh.ch.
• J Gen Intern Med. 2018 Jul 1; 33 (7): 1052-1059.

BackgroundIn the last decade, the number of patients continuously deeply sedated until death increased up to fourfold. The reasons for this increase remain unclear.ObjectiveTo identify socio-demographic and clinical characteristics of sedated patients, and concurrent possibly life-shortening medical end-of-life decisions.DesignCross-sectional death certificate study in German-speaking Switzerland in 2001 and 2013.ParticipantsNon-sudden and expected deaths (2001: N = 2281, 2013: N = 2256) based on a random sample of death certificates and followed by an anonymous survey on end-of-life practices among attending physicians.Main MeasuresPhysicians' reported proportion of patients continuously deeply sedated until death, socio-demographic and clinical characteristics, and possibly life-shortening medical end-of life decisions.Key ResultsIn 2013, physicians sedated four times more patients continuously until death (6.7% in 2001; 24.5.5% in 2013). Four out of five sedated patients died in hospitals, outside specialized palliative care units, or in nursing homes. Sedation was more likely among patients younger than 65 (odds ratio 2.24, 95% CI 1.6 to 3.2) and those dying in specialized palliative care (OR 2.2, 95% CI 1.3 to 3.8) or in hospitals (1.7, 95% CI 1.3 to 2.3). Forgoing life-prolonging treatment with the explicit intention to hasten or not to postpone death combined with intensified alleviation of symptoms was very strongly associated with continuous deep sedation (OR 6.8, 95% CI 4.7 to 9.8).ConclusionsIn Swiss clinical practice, continuously deeply sedated patients predominantly died outside specialized palliative care. The increasing trend over time appears to be related to changes in medical end-of-life practice rather than to patient's clinical characteristics.

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