• J. Int. Med. Res. · Oct 2014

    Comparative Study

    Noninvasive ventilation with complex critical care ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

    • Jing Zhang, Yan Wang, Jie Cao, Bao-Yuan Chen, and Jing Feng.
    • Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China.
    • J. Int. Med. Res. 2014 Oct 1; 42 (5): 1102-9.

    ObjectiveTo compare the clinical effect of noninvasive positive-pressure ventilation (NIPPV), delivered via critical care ventilator or miniventilator, in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).MethodsProspective comparison study. Patients with AECOPD underwent NIPPV via: miniventilator with BiLevel positive airway pressure (BiPAP; Group A); critical care ventilator with pressure support ventilation and positive end expiratory pressure (PSV + PEEP; Group B); critical care ventilator with pressure-synchronized intermittent mandatory ventilation (P-SIMV)+PSV + PEEP (Group C). Physiological parameters were recorded before, during and after ventilation.ResultsPatients in Group C (n = 21) showed significantly better improvements in physiological parameters (compared with pretreatment values) than those in Group B (n = 20) or Group A (n = 22).ConclusionNIPPV delivered via critical care ventilator has a better treatment effect than miniventilator NIPPV in patients with AECOPD. The use of P-SIMV + PSV + PEEP mode provides a significantly better treatment effect than PSV + PEEP alone.© The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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