• Kan Zhang, Richard Sheu, Nicole M Zimmerman, Andrej Alfirevic, Shiva Sale, A Marc Gillinov, and Andra E Duncan.
• Anesthesiology Institute, Cleveland Clinic, Cleveland, OH.
• J. Cardiothorac. Vasc. Anesth. 2019 May 1; 33 (5): 1315-1322.

ObjectiveMyocardial strain measured by speckle-tracking echocardiography detects subtle regional and global left ventricular dysfunction. Myocardial strain is measured in the longitudinal, circumferential, and radial dimensions; however, it is unclear which dimension of strain is the best predictor of postoperative outcomes.DesignA secondary analysis of prospectively collected data from a clinical trial (NCT01187329).SettingThe cardiothoracic surgical operating rooms of an academic tertiary-care center.ParticipantsCardiothoracic surgery patients with aortic stenosis having aortic valve replacement (AVR) with or without coronary artery bypass grafting enrolled in a clinical trial.InterventionsMyocardial deformation analysis from standardized investigative transesophageal echocardiographic examinations performed after induction of anesthesia.Measurements And Main ResultsThe authors compared the ability of intraoperative global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) strain to predict adverse postoperative outcomes, including prolonged hospitalization and the need for pharmacologic hemodynamic support after cardiac surgery. The association of GLS, GCS, and GRS with prolonged hospitalization (>7 days) and the need for pharmacologic hemodynamic support, with epinephrine or norepinephrine after cardiopulmonary bypass, were assessed using separate multivariable logistic regression models with adjustment for multiple comparisons. Of 100 patients, 86 had acceptable measurements for GLS analysis, 73 for GCS, and 72 for GRS. Worse GLS was associated with prolonged hospitalization [odds ratio [OR] (98.3% confidence interval [CI]) of 1.21 (1.01-1.46) per-unit worsening in strain (p = 0.01, significance criterion <0.0167)] and the need for inotropic support with epinephrine [OR (99.2% CI) of 1.81 (1.10-2.97) per-unit worsening in strain (p = 0.002, significance criterion <0.0083)], but not norepinephrine. GCS and GRS were not associated with adverse outcomes.ConclusionGLS, but not GCS or GRS, predicts prolonged hospitalization and the requirement for inotropic support with epinephrine after AVR.Copyright © 2018 Elsevier Inc. All rights reserved.

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