• Anesthesia and analgesia · Mar 2019

    Review

    Impact of Anesthetics on Human Neutrophil Function.

    • Angela Meier and Victor Nizet.
    • From the Department of Anesthesiology, Division of Critical Care, University of San Diego, San Diego, California.
    • Anesth. Analg. 2019 Mar 1; 128 (3): 569-574.

    AbstractAnesthetics are widely used drugs administered in a multitude of clinical settings. Their impacts on various functions of the immune system have been studied but are still not fully understood. Neutrophil granulocytes are a critical first-line host defense mechanism against infections and contribute to the inflammatory phase of wound healing, but dysregulated neutrophil activation can also precipitate perioperative organ injury. A better understanding of the interactions between common anesthetics and neutrophils may reveal considerations toward optimizing treatment of our most vulnerable patients in the intensive care unit and in the perioperative setting.

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