• Critical care clinics · Apr 2019

    Review Meta Analysis

    Hormone Therapy in Trauma Patients.

    • Karim Asehnoune, Mickael Vourc'h, and Antoine Roquilly.
    • EA3826 Thérapeutiques Anti-Infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Medical University of Nantes, 21 boulevard Benoni Goullin, Nantes 44000, France; Surgical Intensive Care Unit, Hotel Dieu, CHU Nantes, 1 place alexis ricordeau, Nantes 44093, France. Electronic address: karim.asehnoune@chu-nantes.fr.
    • Crit Care Clin. 2019 Apr 1; 35 (2): 201-211.

    AbstractLow-dose hydrocortisone reduces the dose of vasopressors and hospital length of stay; it may also decrease the rate of hospital-acquired pneumonia and time on ventilator. No major side effect was reported, but glycemia and natremia should be monitored. Progesterone did not enhance outcome of trauma patients. A meta-analysis suggested that oxandrolone was associated with shorter length of stay and reduced weight loss. Erythropoietin did not enhance neurologic outcome of traumatic brain-injured patients; such treatment, however, could reduce the mortality in subgroups of patients. This review focuses mainly on glucocorticoids, which are the most extensively investigated treatments in hormone therapy.Copyright © 2018 Elsevier Inc. All rights reserved.

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