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Clinical Trial
Possible link between anaphylactoid reactions to anaesthetics and chemicals in cosmetics and biocides.
- A Weston and E S Assem.
- Pharmacology Department, University College London, UK.
- Agents Actions. 1994 Jun 1; 41 Spec No: C138-9.
AbstractBinding-inhibition studies involving human IgE antibody to suxamethonium, SUX (from a patient with a near-fatal reaction), were performed with five different quaternary ammonium compounds (QAC): three common ingredients of cosmetics and two commonly used disinfectants, cetrimide and benzalkonium. All the five QAC showed immunological cross-reaction with SUX. In addition, at high concentrations, they released histamine from basophils of normal subjects. Thus, QAC may be both sensitizers and histamine releasers.
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