• Fernanda Ferreira Cruz, Lorenzo Ball, Rocco Patricia Rieken Macedo PRM a Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics , Federal University of Rio de Janeiro , Rio de Jane, and Paolo Pelosi.
• a Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
• Expert Rev Respir Med. 2018 May 1; 12 (5): 403-414.

IntroductionMechanical ventilation is required to support respiratory function in the acute respiratory distress syndrome (ARDS), but it may promote lung damage, a phenomenon known as ventilator-induced lung injury (VILI). Areas covered: Several mechanisms of VILI have been described, such as: inspiratory and/or expiratory stress inducing overdistension (volutrauma); interfaces between collapsed or edema-filled alveoli with surrounding open alveoli, acting as stress raisers; alveoli that repetitively open and close during tidal breathing (atelectrauma); and peripheral airway dynamics. In this review, we discuss: the definition and classification of ARDS; ventilatory parameters that act as VILI determinants (tidal volume, respiratory rate, positive end-expiratory pressure, peak, plateau, driving and transpulmonary pressures, energy, mechanical power, and intensity); and the roles of prone positioning and muscle paralysis. We seek to provide an up-to-date overview of the evidence in the field from a clinical perspective. Expert commentary: To prevent VILI, mechanical ventilation strategies should minimize inspiratory/expiratory stress, dynamic/static strain, energy, mechanical power, and intensity, as well as mitigate the hemodynamic consequences of positive-pressure ventilation. In patients with moderate to severe ARDS, prone positioning can reduce lung damage and improve survival. Overall, volutrauma seems to be more harmful than atelectrauma. Extracorporeal support should be considered in selected cases.

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