• Qingbing Wang, Yi Chen, Xiaolin Wang, Gaoquan Gong, Guoping Li, and Changyu Li.
• Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China; Shanghai Institute of Medical Imaging, Shanghai 200032, PR China.
• Eur. J. Cancer. 2014 May 1; 50 (8): 1498-509.

Background And AimsQuantification of the association between consumption of fruit and vegetables and risk of gastric cancer (GC) is controversial. We aimed to conduct a meta-analysis of cohort studies to evaluate the associations.MethodsEligible studies published up to 31st August 2013 were retrieved via both computer searches of PubMed and EMBASE and a manual review of references. Random-effects models were used to calculate summary relative risk (SRR). Heterogeneity among studies was assessed using Cochran's Q and I(2) statistics.ResultsA total of 17 articles (24 studies), were included in this meta-analysis. There were >2.4 million individuals (6632 GC events) with a median follow-up of 10years. Based on the high versus low analysis, consumption of fruit, but not vegetables, may reduce risk of gastric cancer (fruit: SRR=0.90, 95% confidence interval (CI): 0.83-0.98, Pheterogeneity=0.450; vegetable: SRR=0.96, 95% CI: 0.88-1.06, Pheterogeneity=0.150). Meta regression analysis suggested that outcome (incidence versus mortality) and study quality (high versus low) contributed significantly to heterogeneity. The same results were also shown in the linear dose-response analysis (per 100-g/day) (fruit: SRR=0.95, 95% CI: 0.91-0.99; vegetable: SRR=0.96, 95% CI: 0.91-1.01). Significant inverse associations emerged in non-linear models for consumption of fruit (Pnon-linearity=0.04), but not for consumption of vegetables (Pnon-linearity=0.551).ConclusionsFindings from this meta-analysis indicate a significant protective effect for the consumption of fruit on GC risk, but not for the consumption of vegetables.Copyright © 2014 Elsevier Ltd. All rights reserved.

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