• Phillip M Trusty, Mike Tree, Kevin Maher, Timothy C Slesnick, Kirk R Kanter, Ajit P Yoganathan, and Shriprasad R Deshpande.
• Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Ga.
• J. Thorac. Cardiovasc. Surg. 2019 Nov 1; 158 (5): 1413-1421.

ObjectiveRight-sided mechanical circulatory support for failing Fontan physiology has been largely unsuccessful due to inherent hemodynamic differences between these patients and the target populations for most assist devices. This study uses advanced benchtop modeling of Fontan physiology to examine the use of PediMag and CentriMag to improve failing Fontan hemodynamics.MethodsEach device was attached to a compliance-matched, patient-specific total cavopulmonary connection in vitro model that used resistances, compliances, and programmable waveforms to establish "failing Fontan" baseline hemodynamics (cardiac output [CO] = 3.5 L/min and central venous pressure ∼17 mm Hg). The ability of the assist devices to improve failing Fontan hemodynamics (reduce inferior vena cava pressure and augment CO) was investigated.ResultsRequiring complete Fontan pathway restriction, PediMag reduced inferior vena cava pressure by ∼10 mm Hg and supported CO augmentation up to 5 L/min. This was accompanied by an increase in superior vena cava pressure of ∼6 mm Hg. CentriMag produced similar hemodynamic changes without the need for pathway restriction or an increase in superior vena cava pressure.ConclusionsPediMag and CentriMag right-sided support led to a decrease in inferior vena cava pressure and augmentation of cardiac output. In the case of CentriMag, this is accomplished without an increase in superior vena cava pressure or the need for restrictive banding. This work provides further data to help with the optimal design of a Fontan assist device to ameliorate the growing need.Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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