• Cancer metastasis reviews · Jun 2015


    Targeting roles of inflammatory microenvironment in lung cancer and metastasis.

    • Lin Shi, Lingyan Wang, Jiayan Hou, Bijun Zhu, Zhihui Min, Miaomiao Zhang, Dongli Song, Yunfeng Cheng, and Xiangdong Wang.
    • Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Biomedical Research Center, Fudan University, Shanghai, China.
    • Cancer Metastasis Rev. 2015 Jun 1; 34 (2): 319-31.

    AbstractInflammatory cells and mediators are essential components in tumor microenvironment and play decisive roles in the initiation, proliferation, survival, promotion, invasion, or metastasis of lung cancer. Clinical and epidemiologic studies suggested a strong association between inflammation and lung cancer and an influence of immune surveillances and tumor responses to chemotherapeutic drugs, although roles of inflammation in lung cancer remain unclear. The present review outlined roles of inflammation in lung cancer, with particular focus on inflammatory components, types, biomarkers, or principal mechanisms by which the inflammation contributes to the development of lung cancer. The cancer-associated inflammatory cells (CICs) should be furthermore defined and include cancer-specific and interacted cells with inflammatory or inflammation-like characteristics, e.g., innate or adaptive immune cells and cancer tissue cells. We also discuss targeting potentials of inflammation in the prevention and treatment of lung cancer. The diversity of cancer-related inflammatory microenvironment is instrumental to design novel therapeutic approaches for lung cancer.

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