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Critical care medicine · Sep 2000
ReviewNew therapeutic implications of anticoagulation mediator replacement in sepsis and acute respiratory distress syndrome.
- J L Vincent.
- Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium. jlvincen@ulb.ac.be
- Crit. Care Med. 2000 Sep 1; 28 (9 Suppl): S83-5.
ObjectiveTo examine the relationship between the coagulation and immune systems in sepsis and acute respiratory distress syndrome and to review published experimental and clinical studies that use anticoagulation mediator replacement strategies in these conditions.Data SourcesMEDLINE database and bibliographies of relevant articles.Study SelectionArticles (both original and review) relating to coagulation abnormalities and anticoagulation mediator replacement therapy in sepsis and acute respiratory distress syndrome.Data ExtractionAll applicable data were extracted.ConclusionsCoagulation abnormalities are common in the critically ill. Early studies using anticoagulation mediator replacement in patients with sepsis have suggested beneficial effects on organ function and outcome. The results from larger, randomized controlled trials are eagerly anticipated.
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