• Journal of neurotrauma · Dec 2019

    Review

    Elucidating the Role of ApoE Isoforms in Spinal Cord Injury-Associated Neuropathology.

    • Carlos A Toro, Dibash K Das, Dongming Cai, and Christopher P Cardozo.
    • National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA, Bronx, New York.
    • J. Neurotrauma. 2019 Dec 15; 36 (24): 331733223317-3322.

    AbstractSpinal cord injury (SCI) is a devastating, life-altering, neurological event that affects ∼300,000 individuals in the United States. Currently, there are no effective treatments to reverse the neurological impairments caused by the lesion. Until a cure is available, there is an urgent need for strategies that can either spare injured neurons or promote neuroplasticity and functional recovery. Genetic links to outcomes after SCI may provide insights into the pathological mechanisms, and possible new avenues for drug development. In the present review, we discuss the current knowledge linking apolipoprotein E genotypes with better or worse functional outcomes after an SCI, and the possible molecular mechanisms that may contribute to this association.

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