• N. Engl. J. Med. · Mar 1963

    Hepatic necrosis associated with halothane anesthesia.

    One of the earliest published case series linking post-operative hepatic necrosis to halothane anaesthesia.

    We now know this occurs in about 1 in 10,000-30,000 adult halothane anaesthetics, and 1 in 60,000 in children, with a historical mortality of 30-70%. In 20% of cases the hepatitis is mild and self-limiting.

    summary
    • J LINDENBAUM and E LEIFER.
    • N. Engl. J. Med. 1963 Mar 7; 268: 525-30.

    no abstract available

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    This article appears in the collection: Landmark articles in Anesthesia.

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    summary
    1

    One of the earliest published case series linking post-operative hepatic necrosis to halothane anaesthesia.

    We now know this occurs in about 1 in 10,000-30,000 adult halothane anaesthetics, and 1 in 60,000 in children, with a historical mortality of 30-70%. In 20% of cases the hepatitis is mild and self-limiting.

    Daniel Jolley  Daniel Jolley
     
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