• Stéphanie Barnay-Verdier, Lakhdar Fattoum, Chloé Borde, Srini Kaveri, Sébastien Gibot, and Vincent Maréchal.
• Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMRS 872, escalier F 2ème étage, 15 rue de l'école de médecine, Paris 75006, France. stephanie.barnay-verdier@upmc.fr
• Intensive Care Med. 2011 Jun 1; 37 (6): 957-62.

PurposeTo assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.MethodsAnti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control.ResultsIgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p<0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p=0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived.ConclusionsThis study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock.© Copyright jointly held by Springer and ESICM 2011

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